View Full Version : Amitriptyline

18th December 2014, 09:48
I have been prescribed Amitriptyline to help control my drooling. Been taking it for a week, starting at one 10 mgs tablet at night and working up to two. So far it has had no effect on the drooling, but I am sleeping rather heavy but for short periods and having vivid, sometimes frightening dreams. We have been told by my specialist nurse and a pharmacist that these type of drugs take time to build up, anything up to four weeks. Has anyone else had experience of Amitriptyline?

18th December 2014, 10:35

Amytriptyline is an antidepressant primarily. My wife was prescribed it from very early on. Dry mouth is one possible side effect which is why it can be prescribed as in your case. Here is a link to a page of information which repeats that it can take up to 4 weeks to see the full effect.



18th December 2014, 11:37
Fully agree with John. Amitriptylene is primarily an antidepressant but is used for other purposes. It is used for chronic pain control because of it's CNS sedative effects. It does result in vivid dreams, dry mouth, grogginess on waking etc. Some people prefer a morning dose. It does take about 4 weeks to build up levels to have an anti-depressant effect. I have no knowledge of the drooling effect other than its effect of causing dry mouth and thus suppressing salivation. As always I wish you the best in finding ways of managing symptoms.



18th December 2014, 19:15
I have amitriptyline for hip and leg pain which used to wake me every couple of hours. It works but has had no effect on my drooling but, as we have often pointed out, we are all different so it might well work for you Trevor.

Big Steve
18th December 2014, 19:28
Hi Trevor
I am taking Lithium Orotate and Vit D3 to try and hold back this disease.
It gives me a dry mouth. Check Google for confirmation.


18th December 2014, 19:49
Jean was described it when she was originally diagnosed with functional weakness. I dont think it's usually used as an antidepressant nowadays as there are more effective ones available. Initially Jean worked up to 30mg and complained of dry mouth all the time. At one point she was taking 75mg but other than the dry mouth she didn't seem to have any problems with it.

It does take time to kick in.

Alison x

19th December 2014, 13:23
Hi Trevor

Amitriptyline made me feel tired through most of the day so I was put on Nortriptyline, which is similar. Might be worth asking your GP about this alternative if the dreams persist and are problematic. I gave up on Nortriptyline later on as the drooling came back after initially being better.

Good luck.

4th January 2015, 11:53
I have been off the drug for a week now. Looking back it gave me two main side effects which I was not happy with. The first was a constant urge to wee and the second an irregular heart best. It is good to be back to normal, will see the GP tomorrow and my consultant next week so hopefully they can recommend something else for the drooling which is very bad.

4th January 2015, 11:59
My husband has been prescribed this to help pain and cramp but it took a month to take effect he sleeps better now and it's kept him at on an even keel he is also taking quinine as well seems to be working well for him

4th January 2015, 18:25
Hi Trevor

I have been on amatriptoline for 10 years or so for depression at one point I was on 200mg per day but I was asleep most of the day so decided to reduce my dosage I'm now taking 60mg per day

I constantly have a dry mouth so it should help in the long term although they may need to up your dosage a little to have an effect I'm taking it at the moment to help with sleep

I too had problematic dreams but these went after a few months amatriptoline was give to my friend as his nerve endings have become damaged it can also be given for migraines

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