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peepyh
20th August 2011, 11:57
Has anyone else had uncontrollable laughing fits and how have they dealt with them? I tend to start laughing at mealtimes, which usually ends with me choking or spraying food and drink all over the table. Or I laugh during arguments with my partner - not helpful!! My partner says it's the hardest/most disconcerting of my symptoms. I'm on 60mg citalopram but they don't seem to have helped.


BTW - on the first attempt at typing this I got to the end and then myy twitchy fingers somehow deleted it!! Annoying!!

Jeannie
20th August 2011, 13:35
I think most if not all have uncontrollable emotions of either crying or laughing or both. Mine seem to have calmed down over the years, however, I still have my days. I think the worst part for me was when my daughter use to fall over as I would be in fits of laughter obviously she did not think it was funny and the more I tried to stop the harder I would laugh. The same with arguments or telling the kids off, who is gonna take you seriously when your either laughing or have the biggest grin on your face imaginable lol I have never taken anything to try and stop it even though it can get embarrassing at times.

They say laughter is the best medicine ;-)

sarahezekiel
20th August 2011, 21:34
I have the same problem. Like Jeannie, it seems to better now, especially the crying. I don't like going to school shows because I always embarrass my children. I've never tried medication. I always try to think of something really sad, to stop laughing. I hate it. Looking back, it was my first symptom. I didn't know what was going on!

Jeannie, aren't there some posts on PatientsLikeMe about what drugs people take?

Sarah

sarahezekiel
20th August 2011, 21:54
PS. I just had a look at PatientsLikeMe and the meds for emotional lability are listed here (http://www.patientslikeme.com/symptoms/show/8)

Amitriptyline is the most commonly used drug, with Citalopram second. There's a long list, including Marijuana. That could make you laugh more!

Hope this helps.

Sarah

peepyh
21st August 2011, 12:07
Thanks Jeannie and Sarah

The only thing I can compare it to is having the giggles whilst stoned - so I agree marijuana might be counter-productive! But it's no fun at all. Today I was trying to groom my dog, and every time I managed to coax him onto the sofa I would suddenly guffaw loudly and scare him off. I'm seeing my doctor next month so will ask re medication.

I thought my crying bouts were just a rational reaction to having MND - how can one tell if they're a symptom?

angnmick
21st August 2011, 12:23
I'd like to say as Micks wife that he usually starts laughing uncontrollably when we are arguing but then that only ends up with us both laughing so maybe EL isn't so bad after all it actually deflates the rows in our house. xx Ang

sarahezekiel
21st August 2011, 16:21
Peepyh

I think that if you find it really difficult to stop crying, it's probably a symptom. As you're experiencing the laughing, it's more than likely emotional lability. I used to cry before MND, but could stop myself after a while. Now I can't.

I think you're very conscious of it and that makes it worse. It will get better in time and maybe you can find a medication that will help. You might want to try hypnotherapy. It could help you find a method of dealing with it.

Ang, I had terrible trouble when I kept laughing at my ex-husband. It made him really angry but I couldn't stop! I'm glad that you and Mick can laugh together!

Best wishes

Sarah

angnmick
22nd August 2011, 20:21
Thanks Sarah, he's been giggling all day today at nothing and its made me smile. Just wish he wouldn't get so stressed out over the little stuff but maybe thats EL too in its own way. Ang xx

luce
22nd August 2011, 22:54
Thanks Sarah, he's been giggling all day today at nothing and its made me smile. Just wish he wouldn't get so stressed out over the little stuff but maybe thats EL too in its own way. Ang xx

HI all
my mum asked me to put up " I laugh when i am alone in town, in my wheelchair.... I just get out my mobile phone and pretend i am talking to someone. Once i wanted to get on a bus and couldn't stop laughing. I kept going to the next bus stop (but was still laughing so could not wheel onto the bus)- 3 miles later and over an hour later I eventually arrived at my sisters house."

Margaret
(typed by Luce)

miranda
23rd August 2011, 11:11
There is some info on Neudexta which is now available in the USA on the mnda website. I know that Prof Kevin Talbot was recently giving evidence in support of approval for prescription here.

Robyn Copley-Hirst
23rd August 2011, 14:13
There is some info on Neudexta which is now available in the USA on the mnda website. I know that Prof Kevin Talbot was recently giving evidence in support of approval for prescription here.

This is a link to a story which I believe is the one miranda refers to. It was on the MND Association website back in December, 2010. I hope it's of interest to those of you reading this who are new to this information.

http://www.mndassociation.org/research/news_in_research/new_drug_for.html

Best Regards,

Robyn

peepyh
23rd August 2011, 17:15
Thanks Miranda and Robyn

That would be helpful, but how frustrating that it is not available in Europe yet!! Or so I take it from the news story? So I can't even harass my doctor for it.

Can/does the MNDA lobby private firms to get on with such registration applications?

PoetChristopherRobin
25th August 2011, 12:03
Had the same thing whem my Wife used to scold me, I laughed at her every time, it stopped itself eventually, but was also a great excuse to ignore her scolding

Now she gets angry at me as if my having this is of my choice?

Robyn Copley-Hirst
30th August 2011, 13:28
Thanks Miranda and Robyn

That would be helpful, but how frustrating that it is not available in Europe yet!! Or so I take it from the news story? So I can't even harass my doctor for it.

Can/does the MNDA lobby private firms to get on with such registration applications?

Hi peepyh,

We'll keep you posted of any news on this area via our main website: www.mndassociation.org

For now I can only tell you that Avanir Pharmaceuticals will be arranging meetings with European regulatory authorities in 2011 and refining their plans for filing for licensing of Nuedexta in Europe. It is not yet possible to say when Nuedexta will be available to people with MND in the UK.

When we know anything else in more detail we will make this known. At this stage it looks as if everything is in hand and there is no reason for us to raise our voice at this stage. They have announced clearly that they intend to get it to the market in Europe, but ultimately it’s not a quick business.

Best Regards,

Robyn

Robyn Copley-Hirst
6th October 2011, 09:27
Drug for uncontrollable laughing and crying is moving toward European licensing

For those of you that haven't seen the update on our research blog yet:

In December last year, we told you about a new drug for uncontrollable laughter and crying (known as the pseudobulbar affect) called Nuedexta that had been approved for use by the Food and Drugs Agency in the USA, and that plans were in place to start the process to gain a European license for the drug in 2011. A number of people affected by this particular symptom of MND have asked us for an update on the progress of Nuedexta, which may also be helpful to others...continue reading here... (http://mndresearch.wordpress.com/2011/10/06/nuedexta/)

I hope the article is of interest to those of you in this thread,

Best Regards,

Robyn

miranda
6th October 2011, 12:23
Thanks Robyn. Good to know progress is being made.

MND Connect helpline