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    It all depends on the numbers of each...

    It all depends on the numbers of each combination. Most will be taking Riluzole I expect. So yes, they will most certainly only be able to be sure of the combination!
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    No confusion at all guys. This is all excellent...

    No confusion at all guys. This is all excellent discussion.

    Yes the earlier trial did have Riluzole in you are correct.

    Platform trials are very very interesting. However, we must not get...
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    I dont suggest in anyway getting drugs outside...

    I dont suggest in anyway getting drugs outside of the trial guys. Sorry shouldnt have mentioned that.

    I am waiting to see what pre-clinical has lead to these trials. This might be a great trial,...
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    We know Riluzole works, and its the only drug...

    We know Riluzole works, and its the only drug proven over a long time. Edaravone/Radicava is NOT yet.

    We also know Riluzole has more effect than previously thought, some 10% extra life now being...
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    Gemma. They need a large number like 750 because...

    Gemma. They need a large number like 750 because of statistical significance and proposed use of trial platform. 750 is a lot. There are only 300 to 400 in Scotland alive! I would assume max 50%...
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    The idea of repurposing drugs is not new. This...

    The idea of repurposing drugs is not new. This new trial platform is of course interesting.

    There is potentially a lot to be said but I am letting the dust settle a bit.

    With the almost zero...
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    Good spot! Thanks

    Good spot! Thanks
  8. Doug we are close, so close. But it needs...

    Doug we are close, so close. But it needs constant attention.

    New blog post being written as we speak,
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    This of course is great publicity. Is it going...

    This of course is great publicity.

    Is it going to lead to breakthroughs? Time will tell.

    Does anyone know the precise drugs (an alzheimers one and an anxiety one) being proposed. I have asked...
  10. Thread: riluzole

    by Onein300
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    Yes taking a break is the best response. It is a...

    Yes taking a break is the best response. It is a long term drug anyway, so a couple of weeks out wont harm. It might be coincidence as well and not down to a Riluzole.
  11. Its new year and things just occur to me at this time of year...

    Hi forum readers.

    Having had MND for nearly 6 years, I thought I would post the following. Sadly, our community is receiving and losing members daily and I wanted to re-post about my blog, which...
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    Good Saturday folks! It’s my first musings of the...

    Good Saturday folks! It’s my first musings of the year on my #als #mnd blog Onein300!
    Here’s to 2020 and all who sail in her!

    https://wp.me/p5hqWZ-3zc
  13. Thread: Glial cells

    by Onein300
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    I have to agree on one aspect there..

    You hit a proverbial nail on the head. We have to start Centering research. There is an issue with spreading far and wide, and often it merely just funds phds! Now don’t get me wrong, we need the...
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    Hi readers! My final serious post of 2019, and my...

    Hi readers! My final serious post of 2019, and my final devils is in the detail commentary on #mnd #als research. I should be back with a more typical fare post before Xmas!
    ...
  15. Thread: Doddie Weir

    by Onein300
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    Yes it is a great programme. It was a...

    Yes it is a great programme. It was a chiropractor and not a physio, and yes I think it was a bit odd.

    Can you rebuild muscle? Typically not, in average als where lower motor neurones are...
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    Doug oh yes the data on plateaus and quite long...

    Doug oh yes the data on plateaus and quite long small improvements in the natural course of our disease has huge huge implications for trials.

    I will write about some of these in my final devil is...
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    My latest onein300 post ...

    My latest onein300 post

    https://onein300.com/2019/11/22/mad-as-a-hatter/
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    Hi readers. I have just published my 4th post...

    Hi readers.

    I have just published my 4th post within a series of “devil is in the detail” posts on MND Research in my onein300.com blog.

    This one is all about the calls for early access for...
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    Hi readers. It wet, it’s Monday and you all need...

    Hi readers. It wet, it’s Monday and you all need a bit of cheering up. So why bother reading my #als #mnd blog?! However, it is my regular jibberish so I hope it helps with your coffee and or...
  20. Thread: NurOwn

    by Onein300
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    A very quick summary. Nurown is in a phase 3...

    A very quick summary.

    Nurown is in a phase 3 in the USA. It will not end until mid to late next year.

    No access is available outside of trial.

    Right to try was responded to by Brainstorm by...
  21. This is early days but this along with the biogen...

    This is early days but this along with the biogen SOD1 Trial are in my mind the key trials ongoing in the world today.

    Rock on!
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    Hi readers! I am back, onein300 with my living...

    Hi readers! I am back, onein300 with my living with #als #mnd usual fare post. A second will follow tomorrow on research for the aficionados of science and wonder. But for now, it’s just my usual...
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    Andy, The physical exercise evidence is totally...

    Andy,
    The physical exercise evidence is totally flimsy to say the least.

    Fit people definitely notice the disease earlier, as they know their bodies. Also fit people tender to not get killed by...
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    It’s my living with #mnd #als post. This week...

    It’s my living with #mnd #als post. This week pollution, watering cans, adventure, cheese and more!
    https://wp.me/p5hqWZ-2Xu
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    Andy, Sorry I misled you. I mean in your...

    Andy,

    Sorry I misled you.

    I mean in your role as a future Trustee, if elected. Nothing to do with placebo trials. Placebos are vital, end of story.

    Will you solemnly agree to be challenging...
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