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Thread: Ibudilast

  1. #1
    Forum Member
    Join Date
    May 2014


    A new trial of a "ALS" treatment being used in MS trials has been fast tracked by the FDA

    About MN-166 (ibudilast)

    MN-166 (ibudilast) has been marketed in Japan and Korea since 1989 to treat post-stroke complications and bronchial asthma. MediciNova licensed MN-166 (ibudilast) from Kyorin Pharmaceutical for potential utility in relapse-remitting multiple sclerosis (RRMS). Intellectual property was additionally established or obtained by MediciNova in progressive MS and other neurological conditions. MN-166 (ibudilast) is a first-in-class, orally bioavailable, small molecule phosphodiesterase (PDE) -4 and -10 inhibitor and a macrophage migration inhibitory factor (MIF) inhibitor that suppresses pro-inflammatory cytokines and promotes neurotrophic factors. It attenuates activated glia cells, which play a major role in certain neurological conditions. Ibudilast's anti-neuroinflammatory and neuroprotective actions have been demonstrated in preclinical and clinical study results and provide the rationale for its therapeutic utility in neurodegenerative diseases (e.g., progressive MS and ALS), substance abuse/addiction and chronic neuropathic pain.

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  2. #2
    Forum Member Dude's Avatar
    Join Date
    May 2015
    Super, I'll polish my rugby boots up. Dude x

  3. #3
    Forum Member Terry's Avatar
    Join Date
    May 2012
    Thanks Silvia;

    I'm sure some of us will look into it.

    Love Terry

    PS:- My rugby days are over but I'm going to try cage fighting!
    TB once said that "The forum is still the best source for friendship and information."

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