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Motor neuron death

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    Motor neuron death


    Im sure one of you clever people know how to explain this. I thought there would be a good youtube clip but there isnt.

    I just want to know the principle of how the full muscle dies and how long it takes with als. Once the motor neurons start dying do the rest go on mass.

    i know that a motor neuron is a circuit to the muscle fibers. I get that once the circuit is broken, the muscle fibers die from lack of use. But how does it work with the whole muscle failing.

    i keep hearing als is about failing not feeling. So for example standing on your tiptoes becomes impossible once the muscle dies. Its not that it gets harder its impossible. I get that the circuit is gone and the muscle doesnt move. But ive also read that its not about feeling.... so if you could lift a dumbell 10 reps and now you can.only do 5 reps thats not als. I dont get that bit. surely theres a time when the muscle is not yet fully dead, when its weak from some motor neurons dying but not all. Surely thats means you can do 5 reps instead of 10. So why is als not about feeling.

    so using a bicep as an example, there are 774 motor neurons and over 200k muscle fibres in a bicep. Do the neurons die one at a time over many months or years or do they die on mass so the muscle dies quickly at once? Ive read the fast twitch muscles die first, but is there then a gap before the other muscles die. How long would it normally take the fat twitch muscle fibers to die? Ii understand there are also motor pools? How do they fit in with the neuron dying?

    The reason im asking is i felt weakness at least 18 months ago butรจฤ• the arm is still moving. Its weak but it still functional. It moves at full speed and does exactly what i want. But its quite painful to lift heavy things as i can see nearly all of the muscles are thinner. Surely all the nuerons on some muscles would have all died if they go on mass in 18 months?

    Maybe im getting myself confused with it all. Im an accountant so i try and understand all the logic.
    Last edited by Shepster34; 13 February 2021, 07:48.

    You are over thinking this and I for one will not reply to your posts. It's called enabling.
    Bulbar started Jan 2020. Mute and 100% tube fed but mobile and undefeated. Stay Strong ๐Ÿค—๐Ÿ˜˜๐Ÿค—๐Ÿ˜xx


      Bit deep I'd say
      Husband Albert diagnosed PMA Feb 21


        when i can think of something profound i will update this.


          Hi guys.

          Sorry, im new to all this. Just trying to get my head around it all. Hope i didnt cause offence.

          Just crazy late night ramblings when i couldnt sleep.

          Please accept my apologies.


            Shepster don't apologise, its the shock kicking in............brain on overdrive.............I don't think you will have offended anyone on here from what I have seen so far!!

            Easy to say, but try and relax a bit get your head around it........there's plenty of advice to be had

            Best wishes

            Husband Albert diagnosed PMA Feb 21


              I admit that the short sharp shock method leaves a lot to be desired. Apology unneeded but welcome. ๐Ÿ˜x
              Bulbar started Jan 2020. Mute and 100% tube fed but mobile and undefeated. Stay Strong ๐Ÿค—๐Ÿ˜˜๐Ÿค—๐Ÿ˜xx


                Hi Shepster - I understand where you're coming from. We look for a logical explanation of the why's and how's. There's obviously quite a bit still to be understood about progression. I think I doesn't help that there there so little we can do to take positive action. If just required say giving up booze, cutting out fats etc there we'd have more control within ourselves


                • Excellent question Shepster!

                  If you don't understand what MND is, how are we ever to fix the problem???

                  There are many ways that neurones fail unfortunately. It is exactly as you describe with a whole lot more complexity.

                  The best way to get a better understanding of what your MND is, is to get a gene test that looks for a known defect.