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    #1

    Hypoxia therapy

    Has anyone had any experience of intermittent hypoxia (simulated altitude) for respiratory functioning? There seems to be emerging research in the area, does anyone have any further information?

    Thanks
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    #2
    My husband was regularly admitted to hospital with CO2 retention (Hypoxia). His treatment was to be put onto a BiPap machine to extract the CO2. They took blood from his inner wrist to check his levels until they reduced.

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      #3
      Newbie,

      I remember reading about IH some years back and thinking it sounded counter-intuitive, but interesting. The research doesn't seem to have progressed any.

      Good luck with your search. I suspect you need a very good FVC and little phrenic involvement to even consider trying IH?

      Ellie x.
      ​Diagnosed 03/2007. Sporadic Definite ALS/MND Spinal (hand) Onset.
      Eye gaze user - No functional limbs - No speech - Feeding tube - Overnight NIV.
      ​

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        #4
        Thank you for your replies.
        I confess to not knowing much about it. A family member is a sports scientist and he keeps an eye out for anything als/MND related.
        I mentioned it to my consultant and he was unaware. If anyone is interested, these are the links he sent me.

        Unexpected benefits of intermittent hypoxia:

        Unexpected Benefits of Intermittent Hypoxia: Enhanced Respiratory and Nonrespiratory Motor Function
        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073945/
        Intermittent hypoxia (IH) is most often thought of for its role in morbidity associated with sleep-disordered breathing, including central nervous system pathology. However, recent evidence suggests that the nervous system fights back in an attempt to ...


        Intermittent hypoxia and stem cell implants preserve breathing capacity:

        Intermittent Hypoxia and Stem Cell Implants Preserve Breathing Capacity in a Rodent Model of Amyotrophic Lateral Sclerosis
        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733409/
        Rationale: Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease causing paralysis and death from respiratory failure. Strategies to preserve and/or restore respiratory function are critical for successful treatment. Although breathing ...


        Intermittent hypoxia and respiratory plasticity:

        Invited review: Intermittent hypoxia and respiratory plasticity - PubMed
        https://www.ncbi.nlm.nih.gov/pubmed/11356815
        Intermittent hypoxia elicits long-term facilitation (LTF), a persistent augmentation (hours) of respiratory motor output. Considerable recent progress has been made toward an understanding of the mechanisms and manifestations of this potentially important model of respiratory plasticity. LTF is elic …

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          #5
          Hi, Is this all about nerve stimulation? I read that if you hum a song and then stick your head in cold water that stimulates the phrenic nerve. My other half does this every day but this is not a recommendation just something he does. Fru

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