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Actimed Licenses European Rights to ACM-002 for Treating ALS

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  • jd58
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    ACM-002 is composed of a medication often used to treat high blood pressure, chest pain, and irregular heartbeat. It targets three biological mechanisms involved in muscle waisting: anabolism, or the building of complex molecules out of smaller ones; catabolism, which is the part of the metabolism responsible for breaking those complex molecules into smaller ones; and fatigue/appetite.

    Importantly, ACM-002 is soluble in fat and can cross the blood-brain barrier easier than other medications of the same class. The blood-brain barrier is a natural protective layer that regulates the transport of molecules between the brain’s blood vessels and brain tissue.

    The company initially licensed and started exploring this molecule for the treatment of cachexia — the changes in appetite and metabolism that cause extreme weight loss and muscle waisting in cancer patients.

    But data has shown that ACM-002 also might be a good treatment candidate for ALS.

    When animal models of ALS carrying a SOD1 mutation were treated with this compound, they lived 33% longer than animals receiving a placebo — 56 versus 42 days. Animals also experienced less muscle loss, as well as fewer reductions in body lean mass, body fat mass, and overall weight.

    Notably, animals receiving a ACM-002 at a dose of 20 mg/kg per day also significantly outlived those given a greater dose of riluzole (30 mg/kg day), an approved medication for ALS, showing the potential of this new medication.

    “… we are delighted to sign this additional licensing agreement with Charité [which] gives us global rights to S-oxprenolol in both potential indications,” said Robin Bhattacherjee, CEO of Actimed Therapeutics. This “position will significantly enhance our options to develop this molecule in cachexia and now ALS.”

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  • nunhead_man
    replied
    Good afternoon and thank you for this – do we know what this stuff does?

    Do we have any of the clinical studies available anywhere?

    Leave a comment:


  • Actimed Licenses European Rights to ACM-002 for Treating ALS

    timed Therapeutics has obtained the rights to develop and commercialize ACM-002 (S-oxprenolol) for the treatment of amyotrophic lateral sclerosis (ALS) in Europe, the company announced.

    The rights, licensed from patent owner Charité University Medicine Berlin, cover all major European markets, including France, Germany, the U.K., Italy, and Spain. Actimed now owns global rights to ACM-002 for this indication

    https://alsnewstoday.com/news-posts/...aign=OneSignal
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