I have recently started an FMT program in Bangkok. I had previously tried Stemcell treatment twice to no avail. There are two ways to undergo the treatment one is via enema direct to the gut and the other is orally with frozen capsules. I have opted for the former which is half the price at $5300 and lasts 10 days. I have posted some info below and welcome comment. I will keep you all informed as regards my progress if any. A ketogenic diet is advised also.
Best wishes Jerry
FMT stands for "fecal microbiota transplant" it is also called HMT for human microbiota transplant. In the case of ALS the goal is to re-balance the gut flora. It means the proportion between different types of bacteria in your gut. As mentioned before, ALS patients are affected by dysbiosis (unbalanced gut flora) and it has been shown than in many progressive neurological conditions the same phenomenon happens. There are many studies showing that the intestinal flora (gut bacteria) is communicating with the brain through the gut-brain axis and that certain gut bacteria can trigger some pathological effects in the brain through the release of neurotoxins. Rebalancing the gut flora may stop this phenomenon as well as improve the immune response (the immune system needs a balanced gut flora to function properly).
We do not have the complete picture about the correlation between the gut microbiome and ALS but we have had 2
stories of patients improving dramatically after FMT treatment (one story from Dr. Thomas Borody, who is the most knowledgeable expert in the world when it comes to the gut microbiome, and the other one was from the friend of a previous patient). That is why we hope that you will be able to improve as well.
Accumulating clinical- and scientific research-based evidence is driving our increased awareness of the significance of the human microbiome (HM) to the healthy and homeostatic operation of the human central nervous system. ALS belongs to neurodegenerative disease characterized by the loss of motor neurons, and the prevalence rate for ALS is substantially lower at 3.9/100000 in the United States (Mehta, 2015). To date, the pathogenesis of ALS remains unclear and is likely multifactorial, and the pathophysiology of ALS may be related to the gastrointestinal tract. The gut microbiota, which is also referred to as the second brain, may affect brain activity through the gut-microbiota–brain axis under both physiological and pathological conditions, and accumulating evidence suggests that microbiota changes in the gastrointestinal tract of individuals possessed strong connection with neurological diseases and specifically, neurodegenerative diseases. In this study, high-throughput sequencing technology was used to compare the microbiota in intestinal tract of healthy people and ALS patients."
"In summary, we found that host microbiota were markedly different in health and disease, and the overgrowing of pathogens and reduction of probiotic organisms in intestines of ALS patients might up-regulated or down-regulated the production of NO, GABA, SCFAs, and LPS, which eventually increased the pathogenesis of ALS, and the ALS conversely aggravated the imbalances of intestinal microbiota, causing a vicious circle for host health. In the present study, we provide basic data to clarify the key bacteria during disease occurring, which may assist our understanding and treatment of ALS by inhibiting the growth of pathogens and enhancing the number of probiotics."
Best wishes Jerry
FMT stands for "fecal microbiota transplant" it is also called HMT for human microbiota transplant. In the case of ALS the goal is to re-balance the gut flora. It means the proportion between different types of bacteria in your gut. As mentioned before, ALS patients are affected by dysbiosis (unbalanced gut flora) and it has been shown than in many progressive neurological conditions the same phenomenon happens. There are many studies showing that the intestinal flora (gut bacteria) is communicating with the brain through the gut-brain axis and that certain gut bacteria can trigger some pathological effects in the brain through the release of neurotoxins. Rebalancing the gut flora may stop this phenomenon as well as improve the immune response (the immune system needs a balanced gut flora to function properly).
We do not have the complete picture about the correlation between the gut microbiome and ALS but we have had 2
stories of patients improving dramatically after FMT treatment (one story from Dr. Thomas Borody, who is the most knowledgeable expert in the world when it comes to the gut microbiome, and the other one was from the friend of a previous patient). That is why we hope that you will be able to improve as well.
Accumulating clinical- and scientific research-based evidence is driving our increased awareness of the significance of the human microbiome (HM) to the healthy and homeostatic operation of the human central nervous system. ALS belongs to neurodegenerative disease characterized by the loss of motor neurons, and the prevalence rate for ALS is substantially lower at 3.9/100000 in the United States (Mehta, 2015). To date, the pathogenesis of ALS remains unclear and is likely multifactorial, and the pathophysiology of ALS may be related to the gastrointestinal tract. The gut microbiota, which is also referred to as the second brain, may affect brain activity through the gut-microbiota–brain axis under both physiological and pathological conditions, and accumulating evidence suggests that microbiota changes in the gastrointestinal tract of individuals possessed strong connection with neurological diseases and specifically, neurodegenerative diseases. In this study, high-throughput sequencing technology was used to compare the microbiota in intestinal tract of healthy people and ALS patients."
"In summary, we found that host microbiota were markedly different in health and disease, and the overgrowing of pathogens and reduction of probiotic organisms in intestines of ALS patients might up-regulated or down-regulated the production of NO, GABA, SCFAs, and LPS, which eventually increased the pathogenesis of ALS, and the ALS conversely aggravated the imbalances of intestinal microbiota, causing a vicious circle for host health. In the present study, we provide basic data to clarify the key bacteria during disease occurring, which may assist our understanding and treatment of ALS by inhibiting the growth of pathogens and enhancing the number of probiotics."
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