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    Ketamine

    The FDA (USA) has designated Ketamine as Orphan Drug. This is validation for the drug as a potential treatment for MND/ALS. PharmaTher has plans to initiate Phase 2 clinical trials, but is only in the stage of protocol discussions with clinicians.
    Do we have any Vets in our forum?

    #2
    Isn't that a horse tranquilliser?
    Bulbar started Jan 2020. Mute and 100% tube fed but mobile and undefeated. Stay Strong 🤗😘🤗😁xx

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      #3
      Well, at least we'd die happy 😂😂😂😘
      Last edited by Ellie; 15 August 2021, 15:09.
      ​Diagnosed 03/2007. Sporadic Definite ALS/MND Spinal (hand) Onset.
      Eye gaze user - No functional limbs - No speech - Feeding tube - Overnight NIV.

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        #4
        Originally posted by matthew55 View Post
        Isn't that a horse tranquilliser?
        It's used on humans too. Paramedics gave it to my daughter when she dislocated her wrist, short acting but good pain relief, which also had her talking gibberish 🥴😍
        ​Diagnosed 03/2007. Sporadic Definite ALS/MND Spinal (hand) Onset.
        Eye gaze user - No functional limbs - No speech - Feeding tube - Overnight NIV.

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          #5
          🐎
          Initial diagnosis 7-4-2021 'suspected MND' confirmed by 2nd opinion 4th June 2021 ALS. Began with R foot limp and lots of falls. Generally weak. Mostly terrified.​​​​​​

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            #6
            Kind of similar to Riluzole, Ketamine can interfere with glutamate. This is the blurb for Ketamine and ALS:

            "Preclinical research reportedly found the compound can safely preserve muscle function and extend survival in animal models of ALS, when given in the early stages of muscle loss.

            In ALS patients, elevated levels of glutamate — a neurotransmitter, or chemical messenger — in the brain and spinal cord cause an overwhelming activation of nerve cells that is toxic and damaging. This occurs partially via glutamate binding to N-methyl-D-aspartate (NMDA) receptors, which overload these neurons with calcium.

            Ketamine indirectly blocks these receptors to potentially inhibit glutamate toxicity. It also lowers the levels of cellular D-serine and partially activates dopamine receptors. Elevated D-serine and low dopamine levels are both associated with ALS.

            Together, these mechanisms may contribute to ketamine being neuroprotective, which could shield the motor neurons that are damaged over the course of ALS."

            ​Diagnosed 03/2007. Sporadic Definite ALS/MND Spinal (hand) Onset.
            Eye gaze user - No functional limbs - No speech - Feeding tube - Overnight NIV.

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              #7
              If it has been used on humans in the UK then could it be classified under whatever Riluzole is classified under?

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                #8
                Originally posted by BobFOwen View Post
                If it has been used on humans in the UK then could it be classified under whatever Riluzole is classified under?
                Because that would take common sense, Bob.... 😏
                ​Diagnosed 03/2007. Sporadic Definite ALS/MND Spinal (hand) Onset.
                Eye gaze user - No functional limbs - No speech - Feeding tube - Overnight NIV.

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                  #9
                  it certainly has been used on humans in the UK in very, uh, non-clinical settings.........

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                    #10
                    Fess up JAC 🤣🤣🤣😘
                    ​Diagnosed 03/2007. Sporadic Definite ALS/MND Spinal (hand) Onset.
                    Eye gaze user - No functional limbs - No speech - Feeding tube - Overnight NIV.

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                      #11
                      solely a friend of a friend of a friend....

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