Fungal and microbial ?

[nunhead_man]

Good afternoon,

Thank you for me as well - I just emailed my neurologist at Kings to give him a heads up and see if they might prescribe the drugs for me.

Best

Andy

[alfadoc]

i had read about the triple anti-viral therapy which was very interesting and despite the small numbers, it suggests the possibilities that a retrovirus is implicated or something other microbe that is not attacked when the immune system is suppressed. The fact that the MND improves once the immune system recovers is very interesting together with the paper from Madrid which increases the likelihood of an infectious process.Unfortunately none of the trials of repurposed drugs are looking at ways to affect the immune system (with the exception of low IL-2).

[Barry52]

Hi Alfadoc,

Triumeq, an antiviral drug used on patients with aids was trialed in Australia for ALS patients with some good results. The trial was too small to prove positive but I believe the trial will be repeated on a bigger scale. Using repurposed drugs will save time and money if they prove successful for MND.

Barry

[alfadoc]

Also when people with AIDS and MND are treated with anti-viral therapy, in some cases (but not all), their MND improves as well. Based on this fact, it suggests that allowing the immune system to recover, the immune cells then attack the substance or organism that it responsible for the MND.

[alfadoc]

Infection?

A further post by Nigel Jones in the same thread - note particularly the last line

Is an underlying infection the cause of MND? As people with AIDS are prone to all types of infection including viruses, bacteria and fungi due to a virus destroying their white cells. It is these infections that kill them not the AIDS virus. Here's the interesting part: MND is 100 times more common in patients with AIDS then the general population

[Dis1960]

A further post by Nigel Jones in the same thread - note particularly the last line

I emailed one of the authors. He replied today.
He recommended Fluconazole 200-400 mg per day and
Doxicicline 100mg every 12 hours, this treatment should be
Continued for six months and then the Neurologist has to evaluate if the treatment has had a positive effect.
I’m going to talk to my MND nurse today about it.
We don’t know if their findings are cause or effect.

[Doug Carpenter]

Many thanks Dis1960.

Fascinating new angle!

Doug

[Terry]

Thanks for the info Dis;

Love Terry

[Dis1960]

Saw this on a Facebook post by Nigel Jones in the group “Life With MND”

“Fungal and bacterial infections consistently found in the central nervous system of ALS/MND patients.
Study concludes sufferers could be treated with existing antimicrobial treatments!”

https://www.frontiersin.org/articles...019.00171/full