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  • Doug Carpenter
    replied
    Thanks Dis1960.

    That looks like a seriously good piece of research! It helps to shed light on how these pesky proteins accumulate.

    Doug

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  • Dis1960
    replied
    Another link from ALS News :

    https://alsnewstoday.com/2019/04/30/...CPDqlTmIgR1CDg

    Leave a comment:


  • Lynne K
    replied
    Thanks for the link Doug. I've saved it to read later as we're busy, busy. Lynne

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  • Lynne K
    replied
    Here's another very interesting piece of research news. Lynne

    https://alsnewstoday.com/2019/04/15/...tm_campaign=On

    Leave a comment:


  • johnburton
    replied
    Hi Doug,
    I'll be going to the FaTHoM event in Oxford on Tuesday, with my siblings. Will you be there?
    John

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  • Doug Carpenter
    replied
    Many thanks for the link Lynne. As you say, an interesting – certainly very thorough – piece of research.

    I mentioned recently the C9orf72 study that I and John Burton are involved in and I’m coming to the view that progress towards at least a partial treatment – though not a cure – may come quicker for familial MND than sporadic MND.

    At least the C9orf72 hexanucleotide repeat and the NMD pathway suggests specific targets for further research. But we need to remember there’s a long road from fruit flies and mouse models to human patients.

    I can’t remember if I’ve posted this link before:

    https://link.springer.com/content/pd...018-8983-8.pdf

    but it’s to a recent paper that I think summarizes very well the present state of knowledge about MND, especially the gene-mediated forms. I’m slightly biased because it’s by the team at the Nuffield Department for Clinical Neuroscience at the John Radcliffe, who look after me so expertly.

    Still a long way to go!

    Doug

    Leave a comment:


  • Lynne K
    started a topic ALS News

    ALS News

    https://alsnewstoday.com/2019/04/11/...aign=OneSignal


    Very interesting report. I think worthy of more research. Lynne
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