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Discovery Of A New ALS And Dementia Disease Mechanism Raises Treatment Hopes

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    Discovery Of A New ALS And Dementia Disease Mechanism Raises Treatment Hopes

    https://vervetimes.com/discovery-of-...-sciencedaily/

    #2
    Thanks aussiegirl xx
    Initial diagnosis 7-4-2021 'suspected MND' confirmed by 2nd opinion 4th June 2021 ALS. Began with R foot limp and lots of falls. NIV overnight. Generally weak. Mostly terrified.​​​​​​

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      #3
      This is the actual study. Cannot access the whole study without subscription.Structure of pathological TDP-43 filaments from ALS with FTLD

      Nature volume 601, pages139–143 (2022)

      Abstract


      The abnormal aggregation of TAR DNA-binding protein 43 kDa (TDP-43) in neurons and glia is the defining pathological hallmark of the neurodegenerative disease amyotrophic lateral sclerosis (ALS) and multiple forms of frontotemporal lobar degeneration (FTLD)1,2. It is also common in other diseases, including Alzheimer’s and Parkinson’s. No disease-modifying therapies exist for these conditions and early diagnosis is not possible. The structures of pathological TDP-43 aggregates are unknown. Here we used cryo-electron microscopy to determine the structures of aggregated TDP-43 in the frontal and motor cortices of an individual who had ALS with FTLD and from the frontal cortex of a second individual with the same diagnosis. An identical amyloid-like filament structure comprising a single protofilament was found in both brain regions and individuals. The ordered filament core spans residues 282–360 in the TDP-43 low-complexity domain and adopts a previously undescribed double-spiral-shaped fold, which shows no similarity to those of TDP-43 filaments formed in vitro3,4. An abundance of glycine and neutral polar residues facilitates numerous turns and restricts β-strand length, which results in an absence of β-sheet stacking that is associated with cross-β amyloid structure. An uneven distribution of residues gives rise to structurally and chemically distinct surfaces that face external densities and suggest possible ligand-binding sites. This work enhances our understanding of the molecular pathogenesis of ALS and FTLD and informs the development of diagnostic and therapeutic agents that target aggregated TDP-43.

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        #4
        Brains, brains. 😂😁😉🤣xx
        Bulbar started Jan 2020. Mute and 100% tube fed but mobile and undefeated. Stay Strong 🤗😘🤗😁xx

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          #5
          Like I can understand this. Anyone able to translate 😳
          when i can think of something profound i will update this.

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            #6
            Originally posted by Johnny5 View Post
            This is the actual study. Cannot access the whole study without subscription.
            That is a different paper to the one about which the OP posted.

            For anyone wanting to read the full scientific paper relating to this thread's topic, published in Nature on 23/02/2022, click here to be bamboozled.

            It is heavy reading but thankfully the MNDA's research blog sums up the paper for us in a much more reader-friendly way, available here
            ​Diagnosed 03/2007. Sporadic Definite ALS/MND Spinal (hand) Onset.
            Eye gaze user - No functional limbs - No speech - Feeding tube - Overnight NIV.

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              #7
              Traditional zombie chant 👿😁😄🤩xx
              Bulbar started Jan 2020. Mute and 100% tube fed but mobile and undefeated. Stay Strong 🤗😘🤗😁xx

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