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Mind Maps: Using neuroimaging to understand the mechanisms of ALS

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    Mind Maps: Using neuroimaging to understand the mechanisms of ALS

    Finding treatments for ALS relies heavily on understanding what is the mechanism of the disease and how it progresses. This study aims to use neuroimaging (such as MRI and PET scans) to acquire pictures of the brain that can help to identify and track potential mechanisms of disease in people living with ALS compared with healthy volunteers. The findings will provide understanding related to the cause of the disease and help to track its progression over time. Most importantly the findings will help with the discovery of new targets for the development of treatments for ALS.

    What does taking part involve?
    The participants will be asked to visit the centre seven times over a period of 12 months.

    The visits will include:
    • Physical examinations
    • Questionnaires
    • Taking biological samples (such as blood and urine)
    • Tests to assess motor and non-motor symptoms
    • MRI (Magnetic Resonance Imaging) scans
    • PET (Positron Emission Tomography) scans

    A thank you sum of £100 per scan to the study participant (up to £800 for the whole duration of the study) will also be offered to participants.

    Who can take part?
    People diagnosed with ALS:
    • Aged 25-85 years old
    • Diagnosed with sporadic ALS and limb disease onset
    • Diagnosis was less than 6 months ago
    • Not pregnant or breastfeeding

    How do I take part?
    For further information about the study and details of how to take part, please contact Dr Edoardo de Natale on [email protected] or 07503741242.
    Alternatively, please contact Mr Martin Howard on [email protected] or 01392 723037.
    You can also visit the MND Association website - MIND MAPS

    Study location
    The study is based in London (Imperial Clinical Research Facility and Invicro London). However, recruitment is open UK-wide. Travel expenses will be reimbursed for the participant and one companion.

    This study is funded by Invicro London.
    Our working hours are Monday to Friday 8:30am until 5pm